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Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management

Upon entering the cytosol, mtDNA can trigger responses by activating four innate immune receptors: cytoplasmic cyclic GMP-AMP synthase (cGAS), TLR9, absent in melanoma 2 (AIM2), and NLRP3

Suhail M, Suhail MZ, Khan H

A total of 640 persons [no cirrhosis 439 (68.6%), cirrhosis 121(18.9%)] and decompensated 80 (12.5%) aged 39.2 15.1 years, 66.1% from rural areas, 63 (9.8%) with diabetes, 96 (15%) with hypertension, 57% treatment experienced, 11% with prior defaulter status were included

Amino acids not only provide the substrate for protein synthesis but also serve as precursors to various metabolic intermediates (14)